Human cathepsin S gene (CTSS) promoter-25G/A polymorphism

被引：8

作者：

Cao, HN ^{[1
]}

Hegele, RA ^{[1
]}

机构：

[1] John P Robarts Res Inst, Blackburn Cardiovasc Genet Lab, London, ON N6A 5K8, Canada

来源：

JOURNAL OF HUMAN GENETICS | 2000年 / 45卷 / 02期

关键词：

atherosclerosis; arterial wall matrix; lipodystrophy;

D O I：

10.1007/s100380050019

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We found a novel G --> A change at nucleotide -25 within the promoter of the CTSS gene encoding the elastase cathepsin S. The CTSS -25G/A polymorphism could be detected by digestion with endonuclease BfmI. The frequency of the CTSS -25A allele was 0.457 in Caucasians and 0.431 in Canadian Inuit. Because of the importance of the CTSS gene product in vascular matrix remodeling, this polymorphism may be useful in the study of associations with atherosclerosis and related phenotypes.

引用

页码：94 / 95

页数：2

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