Molecular characterization of multidrug-resistant Streptococcus pneumoniae isolates in Korea

被引：16

作者：

Song, JH

Yang, JW

Jin, JH

Kim, SW

Kim, CK

Lee, H

Peck, KR

Kim, S

Lee, NY

Jacobs, MR

Appelbaum, PC

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis,Kangnam Ku, Seoul 135710, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Clin Pathol, Seoul 135710, South Korea

[3] Samsung Biomed Res Inst, Seoul, South Korea

[4] Asian Pacific Res Fdn Infect Dis, Seoul, South Korea

[5] Case Western Reserve Univ, Cleveland, OH 44106 USA

[6] Hershey Med Ctr, Hershey, PA USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2000年 / 38卷 / 04期

关键词：

D O I：

10.1128/JCM.38.4.1641-1644.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pulsed-field gel electrophoresis, ribotyping, and fingerprinting analysis of 22 invasive isolates of multidrug-resistant (MDR) pneumococci from Korea showed that 59 to 82% were genetically related. DNA sequencing of the PBP 2B gene showed relatively uniform alterations in nucleotides (5.4 to 7.8%) and amino acids (3.0 to 4.3%), while Asn-276-->Lys, Arg-285-->Cys and Ser-305-->Phe substitutions were unique to Korean MDR strains, suggesting the spread of a few epidemic clones of resistant pneumococci within Korea.

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页码：1641 / 1644

页数：4

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