The immunogenicity of single and combination DNA vaccines against tuberculosis

被引：124

作者：

Morris, S ^{[1
]}

Kelley, C ^{[1
]}

Howard, A ^{[1
]}

Li, ZM ^{[1
]}

Collins, F ^{[1
]}

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Lab Mycobacteria, Bethesda, MD 20892 USA

来源：

VACCINE | 2000年 / 18卷 / 20期

关键词：

tuberculosis; DNA vaccines; combination vaccines;

D O I：

10.1016/S0264-410X(99)00540-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DNA immunization is a promising new approach for the development of novel tuberculosis vaccines. In this study, the immune responses following the administration of single and combination tuberculosis DNA vaccines were evaluated. Single DNA vaccines encoding the MPT-63 and MPT-83 tuberculosis antigens evoked partial protection against an aerogenic challenge with M, tuberculosis Erdman in the mouse model of pulmonary tuberculosis. Immunization with a multivalent combination DNA vaccine (containing the ESAT-6, MPT-64, MPT-63, and KatG constructs) generated immune responses that indicated an absence of antigenic competition since antigen-specific cell-mediated and humoral responses were detected to each component of the mixture. More importantly, the combination vaccine elicited a strong protective response relative to the protection evoked by live BCG vaccine. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2155 / 2163

页数：9

共 43 条

[1] Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis
Andersen, P
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1997, 45 (02) : 115 - 131
[2] [Anonymous], WORLD HLTH REP
[3] Cardona PJ, 1999, SCAND J IMMUNOL, V49, P362
[4] An African perspective on the threat of tuberculosis and HIV/AIDS - can despair be turned to hope?
Chintu, C
Mwinga, A
[J]. LANCET, 1999, 353 (9157) : 997 - 997
[5] THE ROLE OF HELPER T-CELL PRODUCTS IN MOUSE B-CELL DIFFERENTIATION AND ISOTYPE REGULATION
COFFMAN, RL
SEYMOUR, BWP
LEBMAN, DA
HIRAKI, DD
CHRISTIANSEN, JA
SHRADER, B
CHERWINSKI, HM
SAVELKOUL, HFJ
FINKELMAN, FD
BOND, MW
MOSMANN, TR
[J]. IMMUNOLOGICAL REVIEWS, 1988, 102 : 5 - 28
[6] EFFICACY OF BCG VACCINE IN THE PREVENTION OF TUBERCULOSIS - METAANALYSIS OF THE PUBLISHED LITERATURE
COLDITZ, GA
BREWER, TF
BERKEY, CS
WILSON, ME
BURDICK, E
FINEBERG, HV
MOSTELLER, F
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (09): : 698 - 702
[7] PROTECTION TO MICE AFFORDED BY BCG VACCINES AGAINST AN AEROGENIC CHALLENGE BY 3 MYCOBACTERIA OF DECREASING VIRULENCE
COLLINS, FM
[J]. TUBERCLE, 1985, 66 (04): : 267 - 276
[8] DISSEMINATED TUBERCULOSIS IN INTERFERON-GAMMA GENE-DISRUPTED MICE
COOPER, AM
DALTON, DK
STEWART, TA
GRIFFIN, JP
RUSSELL, DG
ORME, IM
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) : 2243 - 2247
[9] Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis
Cooper, AM
Callahan, JE
Keen, M
Belisle, JT
Orme, IM
[J]. TUBERCLE AND LUNG DISEASE, 1997, 78 (01): : 67 - 73
[10] DOLIN PJ, 1994, B WORLD HEALTH ORGAN, V72, P213

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