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Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: longitudinal evaluation of a cohort of prospective brain donors

被引：33
作者：
Adler, CH
Hentz, JG
Joyce, JN
Beach, T
Caviness, JN
机构：
[1] Mayo Clin Scottsdale, Parkinsons Dis & Movement Disorders Ctr, Scottsdale, AZ 85259 USA
[2] Mayo Clin Scottsdale, Biostat Sect, Scottsdale, AZ 85259 USA
[3] Sun Hlth Res Inst, Sun City, AZ USA
来源：
PARKINSONISM & RELATED DISORDERS | 2002年 / 9卷 / 02期
关键词：
brain donation; Parkinson's disease; motor impairment;
D O I：
10.1016/S1353-8020(02)00012-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：103 / 110
页数：8
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