Closed-loop cortical neuromodulation in Parkinson's disease: An alternative to deep brain stimulation?

被引：101

作者：

Beuter, Anne ^{[1
]}

Lefaucheur, Jean-Pascal ^{[2
,3
]}

Modolo, Julien ^{[4
,5
,6
]}

机构：

[1] Inst Polytech Bordeaux, F-33402 Talence, France

[2] Univ Paris Est Creteil, Fac Med, EA 4391, Creteil, France

[3] Hop Henri Mondor, AP HP, Serv Physiol Explorat Fonct, Creteil, France

[4] Lawson Hlth Res Inst, Human Threshold Res Grp, London, ON, Canada

[5] Western Univ, Dept Med Biophys, London, ON, Canada

[6] Western Univ, Dept Med Imaging, London, ON, Canada

来源：

CLINICAL NEUROPHYSIOLOGY | 2014年 / 125卷 / 05期

关键词：

Closed-loop; Cortex; Deep brain stimulation; Functional neurosurgery; Neuromodulation; Parkinson's disease; Treatment; MOTOR CORTEX STIMULATION; LOCAL-FIELD POTENTIALS; SUBTHALAMIC NUCLEUS STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; HIGH-FREQUENCY STIMULATION; BETA-OSCILLATORY ACTIVITY; MOVEMENT-RELATED CHANGES; BASAL GANGLIA; ELECTRICAL-STIMULATION; CEREBRAL-CORTEX;

D O I：

10.1016/j.clinph.2014.01.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Deep brain stimulation (DBS) is usually performed to treat advanced Parkinson's disease (PD) patients with electrodes permanently implanted in basal ganglia while the stimulator delivers electrical impulses continuously and independently of any feedback (open-loop stimulation). Conversely, in closed-loop stimulation, electrical stimulation is delivered as a function of neuronal activities recorded and analyzed online. There is an emerging development of closed-loop DBS in the treatment of PD and a growing discussion about proposing cortical stimulation rather than DBS for this purpose. Why does it make sense to "close the loop'' to treat parkinsonian symptoms? Could closed-loop stimulation applied to the cortex become a valuable therapeutic strategy for PD? Can mathematical modeling contribute to the development of this technique? We review the various evidences in favor of the use of closed-loop cortical stimulation for the treatment of advanced PD, as an emerging technique which might offer substantial clinical benefits for PD patients. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved

引用

页码：874 / 885

页数：12

共 196 条

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A translational platform for prototyping closed-loop neuromodulation systems [J].