Bone marrow mesenchymal stem cells improve myocardial function in a swine model of acute myocardial infarction

被引：46

作者：

Zhao, Jing-Jie ^{[1
]}

Liu, Xiao-Cheng ^{[2
,3
]}

Kong, Feng ^{[4
]}

Qi, Tong-Gang ^{[4
]}

Cheng, Guang-Hui ^{[4
]}

Wang, Jue ^{[4
]}

Sun, Chao ^{[4
]}

Luan, Yun ^{[4
]}

机构：

[1] Shandong Univ, Hosp 2, Clin Mol Biol Lab, Jinan 250033, Shandong, Peoples R China

[2] TEDA Int Cardiovasc Hosp, Tianjin 300457, Peoples R China

[3] Nankai Univ, Coll Med, Tianjin 300457, Peoples R China

[4] Shandong Univ, Hosp 2, Cent Res Lab, Jinan 250033, Shandong, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2014年 / 10卷 / 03期

关键词：

AMI; BMSCs; transplantation; TRANSMYOCARDIAL DEGRADABLE STENT; RESTORE CARDIAC-FUNCTION; GROWTH-FACTOR; TRANSPLANTATION; PROLIFERATION; ANGIOGENESIS; DELIVERY; REPAIR; SIZE;

D O I：

10.3892/mmr.2014.2378

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The aim of the current study was to confirm the effect and elucidate the mechanism of bone marrow mesenchymal stem cells (BMSCs) in acute myocardial infarction (AMI). AMI was induced in mini-swine by ligating the left anterior descending coronary artery, and BMSCs (1x10(7)) were injected via a sterile microinjection into the ischemic area. Six months postoperatively, electrocardiograph-gated single photon emission computed tomography revealed that the myocardial filling defect was reduced and the left ventricular ejection fraction was improved in the BMSC group compared with the control group (P<0.05). Histopathological examination indicated that, in the BMSC treatment group, the percentage of survived myocardial tissue and the vessel density were increased, and the percentage of apoptosis was decreased compared with controls (P<0.05). Reverse transcription-polymerase chain reaction results indicated that the expression levels of multiple inflammatory factors were significantly upregulated in the BMSC group compared with levels in the control group (P<0.05). In conclusion, the present study demonstrated that BMSC injection significantly improved cardiac function and reduced infarct size in six months, indicating that this method may be valuable for future study in clinical trials.

引用

页码：1448 / 1454

页数：7

共 29 条

[1]

Fibroblast growth factor-2 and-4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways [J].