New synthesis of SKF 89976A

被引：8

作者：

Chang, Meng-Yang ^{[1
]}

Wang, Si-Yun

Pai, Chun-Li

机构：

[1] Natl Univ Kaohsiung, Dept Appl Chem, Kaohsiung 811, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 36期

关键词：

3-hydroxypiperidine; Baeyer-Villiger lactonization; 3-tosyl-[1,3]oxazepan-7-one; 4,4-diaryl-3-butenyl-1-amines;

D O I：

10.1016/j.tetlet.2006.06.156

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted 4,4-diaryl-3-butenyl-l-amines are synthesized in nearly 34-47% overall yields starting from 3-hydroxypiperidine by the regioselective Baeyer-Villiger lactonization, Grignard addition and elimination sequence. This facile strategy was also used to synthesize racemic SKF 89976A. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6389 / 6392

页数：4

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