No association between the neuronal nitric oxide synthase gene polymorphism and Alzheimer disease

被引：11

作者：

Liou, YJ

Hong, CJ

Liu, HC

Liu, CY

Liu, TY

Chen, IC

Tsai, SJ

机构：

[1] Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan

[2] Yu Li Vet Hosp, Sect Psychiat, Hualien, Taiwan

[3] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[4] Vet Gen Hosp, Neurol Inst, Taipei 11217, Taiwan

[5] Chang Gung Univ, Sch Med, Dept Psychiat, Taoyuan, Taiwan

[6] Chang Gung Mem Hosp, Taoyuan, Taiwan

[7] Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 2002年 / 114卷 / 06期

关键词：

Alzheimer disease; association; neuronal nitric oxide synthase; polymorphism;

D O I：

10.1002/ajmg.10670

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nitric oxide synthase (NOS) has been implicated in the pathogenesis of Alzheimer disease (AD). To examine the role of the neuronal NOS (nNOS) gene in AD, patients (n =139) and control subjects (n =101) were genotyped for the nNOS dinucleotide polymorphism. No association was demonstrated for AD and this particular nNOS polymorphism. (C) 2002 Wiley-Liss, Inc.

引用

页码：687 / 688

页数：2

共 13 条

[1]

Beal MF, 1998, ANN NEUROL, V44, pS110

[2]

Crawford F, 2000, ANN NEUROL, V47, P687, DOI 10.1002/1531-8249(200005)47:5<687::AID-ANA30>3.3.CO

[3]

2-W

[4]

Dahiyat M, 1999, ANN NEUROL, V46, P664, DOI 10.1002/1531-8249(199910)46:4<664::AID-ANA18>3.0.CO

[5]

2-J

[6] A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma [J].

Grasemann, H ;

Yandava, CN ;

van's Gravesande, KS ;

Deykin, A ;

Pillari, A ;

Ma, J ;

Sonna, LA ;

Lilly, C ;

Stampfer, MJ ;

Israel, E ;

Silverman, EK ;

Drazen, JM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 272 (02) :391-394

[7]

HALL AV, 1994, J BIOL CHEM, V269, P33082

[8] Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type [J].

Law, A ;

Gauthier, S ;

Quirion, R .

BRAIN RESEARCH REVIEWS, 2001, 35 (01) :73-96

[9]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[10]

Rafalowska J, 1998, FOLIA NEUROPATHOL, V36, P211

← 1 2 →