A trace of silence: memory and microRNA at the synapse

被引：59

作者：

Ashraf, Shovan I. ^{[1
]}

Kunes, Sam ^{[1
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2006年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.conb.2006.08.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Identifying the neural circuits that mediate particular behaviors and uncovering their plasticity is an endeavor at the heart of neuroscience. This effort is allied with the elucidation of plasticity mechanisms, because the molecular determinants of plasticity can be markers for the neurons and synapses that are modified by experience. Of particular interest is protein synthesis localized to the synapse, which might establish and maintain the stable modification of neuronal properties, including the pattern and strength of synaptic connections. Recent studies reveal that microRNAs and the RISC pathway regulate synaptic protein synthesis. Is synaptic activity of the RISC pathway a molecular signature of memory?

引用

页码：535 / 539

页数：5

共 43 条

[1] Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila [J].

Ashraf, SI ;

McLoon, AL ;

Sclarsic, SM ;

Kunes, S .

CELL, 2006, 124 (01) :191-205

[2] The persistence of long-term memory: A molecular approach to self-sustaining changes in learning-induced synaptic growth [J].

Bailey, CH ;

Kandel, ER ;

Si, KS .

NEURON, 2004, 44 (01) :49-57

[3] Relief of microRNA-mediated translational repression in human cells subjected to stress [J].

Bhattacharyya, Suvendra N. ;

Habermacher, Regula ;

Martine, Ursula ;

Closs, Ellen I. ;

Filipowicz, Witold .

CELL, 2006, 125 (06) :1111-1124

[4] Activity-dependent dynamics and sequestration of proteasomes in dendritic spines [J].

Bingol, Baris ;

Schuman, Erin M. .

NATURE, 2006, 441 (7097) :1144-1148

[5] Fragile X-related protein and VIG associate with the RNA interference machinery [J].

Caudy, AA ;

Myers, M ;

Hannon, GJ ;

Hammond, SM .

GENES & DEVELOPMENT, 2002, 16 (19) :2491-2496

[6] Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia [J].

Chain, DG ;

Casadio, A ;

Schacher, S ;

Hegde, AN ;

Valbrun, M ;

Yamamoto, N ;

Goldberg, AL ;

Bartsch, D ;

Kandel, ER ;

Schwartz, JH .

NEURON, 1999, 22 (01) :147-156

[7] The Drosophila CPEB homolog, Orb, is required for Oskar protein expression in oocytes [J].

Chang, JS ;

Tan, LH ;

Schedl, P .

DEVELOPMENTAL BIOLOGY, 1999, 215 (01) :91-106

[8]

Chang JS, 2001, DEVELOPMENT, V128, P3169

[9] The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway [J].

Costa, A ;

Wang, Y ;

Dockendorff, TC ;

Erdjument-Bromage, H ;

Tempst, P ;

Schedl, P ;

Jongens, TA .

DEVELOPMENTAL CELL, 2005, 8 (03) :331-342

[10] microPrimer: The biogenesis and function of microRNA [J].

Du, TT ;

Zamore, PD .

DEVELOPMENT, 2005, 132 (21) :4645-4652

← 1 2 3 4 5 →