Structure-based inhibitor design

被引：7

作者：

Craig, SP ^{[1
]}

Eakin, AE ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Lab Mol Parasitol & Drug Design, Chapel Hill, NC 27599 USA

来源：

VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 58 | 2000年 / 58卷

关键词：

D O I：

10.1016/S0083-6729(00)58024-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：149 / +

页数：22

共 63 条

[1] An experimental approach to mapping the binding surfaces of crystalline proteins [J].

Allen, KN ;

Bellamacina, CR ;

Ding, XC ;

Jeffery, CJ ;

Mattos, C ;

Petsko, GA ;

Ringe, D .

JOURNAL OF PHYSICAL CHEMISTRY, 1996, 100 (07) :2605-2611

[2] Structure-based drug design [J].

Amzel, LM .

CURRENT OPINION IN BIOTECHNOLOGY, 1998, 9 (04) :366-369

[3] Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydroquinoxaline-2(1H)-thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2′,3′-dideoxy-3′-thiacytidine (lamivudine) [J].

Balzarini, J ;

Pelemans, H ;

Riess, G ;

Roesner, M ;

Winkler, I ;

De Clercq, E ;

Kleim, JP .

BIOCHEMICAL PHARMACOLOGY, 1998, 55 (05) :617-625

[4]

Bohacek RS, 1996, MED RES REV, V16, P3, DOI 10.1002/(SICI)1098-1128(199601)16:1<3::AID-MED1>3.3.CO

[5]

2-D

[6] DRUGS BY DESIGN [J].

BUGG, CE ;

CARSON, WM ;

MONTGOMERY, JA .

SCIENTIFIC AMERICAN, 1993, 269 (06) :92-98

[7] Bacterial complementation as a means to test enzyme-ligand interactions [J].

Canyuk, B ;

Craig, SP ;

Eakin, AE .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1998, 50 (02) :181-186

[8] Structure-based design of potent inhibitors of scytalone dehydratase: Displacement of a water molecule from the active site [J].

Chen, JM ;

Xu, SL ;

Wawrzak, Z ;

Basarab, GS ;

Jordan, DB .

BIOCHEMISTRY, 1998, 37 (51) :17735-17744

[9] ANALYTICAL MOLECULAR-SURFACE CALCULATION [J].

CONNOLLY, ML .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1983, 16 (OCT) :548-558

[10]

De Clercq E, 1998, Verh K Acad Geneeskd Belg, V60, P13

← 1 2 3 4 5 6 7 →