Skin barrier function in atopic dermatitis

被引：46

作者：

Vickery, Brian P. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Sect Allergy & Clin Immunol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN PEDIATRICS | 2007年 / 19卷 / 01期

关键词：

atopic dermatitis; epithelium; filaggrin; skin barrier function;

D O I：

10.1097/MOP.0b013e328012315a

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Purpose of review Whereas much investigation in atopic dermatitis has focused upon the adaptive immune response, new data suggest that allergic sensitization may occur secondary to impairment to skin barrier function. Recent findings Two common loss of function mutations in the FLG gene encoding filaggrin (an important component of terminal keratinocyte differentiation) are strongly associated with the development of atopic dermatitis and asthma associated with atopic dermatitis. Summary Genetic defects in skin barrier function should be recognized as major factors for the development of atopic dermatitis and asthma.

引用

页码：89 / 93

页数：5

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