A genetic view of iron homeostasis

被引：36

作者：

Andrews, NC

机构：

[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

SEMINARS IN HEMATOLOGY | 2002年 / 39卷 / 04期

关键词：

D O I：

10.1053/shem.2002.35632

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inherited disorders of iron metabolism are invariably disorders of iron balance or distribution. This review describes the proteins known to be involved in establishing and maintaining iron balance, and discusses regulation of iron homeostasis in the context of three cell types: intestinal enterocytes, reticuloendothelial macrophages, and hepatocytes. It emphasizes information gleaned from the use of genetic analyses, particularly in mice, and poses new questions to help advance our understanding of iron balance. Copyright 2002, Elsevier Science (USA). All rights reserved.

引用

页码：227 / 234

页数：8

共 66 条

[1] A novel mammalian iron-regulated protein involved in intracellular iron metabolism [J].