Impact of Diabetes on Epidemiology, Treatment, and Outcomes of Patients With Heart Failure

被引：334

作者：

Dei Cas, Alessandra ^{[1
]}

Khan, Sadiya S. ^{[2
]}

Butler, Javed ^{[3
]}

Mentz, Robert J. ^{[4
]}

Bonow, Robert O. ^{[5
]}

Avogaro, Angelo ^{[6
]}

Tschoepe, Diethelm ^{[7
]}

Doehner, Wolfram ^{[8
]}

Greene, Stephen J. ^{[5
]}

Senni, Michele ^{[9
]}

Gheorghiade, Mihai ^{[5
]}

Fonarow, Gregg C. ^{[10
]}

机构：

[1] Univ Parma, Dept Clin & Expt Med, Unit Diabet & Prevent Associated Dis, I-43100 Parma, Italy

[2] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Cardiol, Chicago, IL 60611 USA

[3] SUNY Stony Brook, Div Cardiol, Stony Brook, NY 11794 USA

[4] Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC 27710 USA

[5] Northwestern Univ, Feinberg Sch Med, Ctr Cardiovasc Innovat, Chicago, IL 60611 USA

[6] Univ Padua, Dept Med, Padua, Italy

[7] Ruhr Univ Bochum, Univ Clin, Heart & Diabet Ctr North Rhine Westfalia, Bochum, Germany

[8] Charite, Ctr Stroke Res, D-13353 Berlin, Germany

[9] Azienda Osped Papa Giovanni XXIII, Cardiovasc Dept, Bergamo, Italy

[10] Ronald Reagan Univ Calif Med Ctr Los Angeles, Ahmanson UCLA Cardiomyopathy Ctr, Los Angeles, CA USA

来源：

JACC-HEART FAILURE | 2015年 / 3卷 / 02期

关键词：

diabetic cardiomyopathy; diabetes mellitus; heart failure; LEFT-VENTRICULAR DYSFUNCTION; POSTDISCHARGE OUTCOMES; MORTALITY; MELLITUS; TRIAL; MORBIDITY; RISK; ALISKIREN; HOSPITALIZATIONS; METAANALYSIS;

D O I：

10.1016/j.jchf.2014.08.004

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) continues to increase with the general aging of the population. In patients with chronic HF, prevalence of DM is 24% compared with 40% in those hospitalized with worsening HF. Patients with concomitant HF and DM have diverse pathophysiologic, metabolic, and neurohormonal abnormalities that potentially contribute to worse outcomes than those without comorbid DM. In addition, although stable HF outpatients with DM show responses that are similar to those of patients without DM undergoing evidence-based therapies, it is unclear whether hospitalized HF patients with DM will respond similarly to novel investigational therapies. These data support the need to re-evaluate the epidemiology, pathophysiology, and therapy of HF patients with concomitant DM. This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies. (C) 2015 by the American College of Cardiology Foundation.

引用

页码：136 / 145

页数：10

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