Nitrile biotransformation by Aspergillus niger

被引：34

作者：

Snajdrová, R

Kristová-Mylerová, V

Crestia, D

Nikolaou, K

Kuzma, M

Lemaire, M

Gallienne, E

Bolte, J

Bezouska, K

Kren, V

Martínková, L

机构：

[1] Acad Sci Czech Republ, Inst Microbiol, Lab Biotransformat, CR-14220 Prague 4, Czech Republic

[2] Univ Clermont Ferrand, SEESIB, F-63177 Clermont Ferrand, France

[3] Charles Univ, Fac Sci, Dept Biochem, CZ-12840 Prague, Czech Republic

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2004年 / 29卷 / 1-6期

关键词：

Aspergillus niger; nitrile-converting enzymes; nitrile hydratase; nitrilase; amidase;

D O I：

10.1016/j.molcatb.2003.12.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A nitrile-converting enzyme activity was induced in Aspergillus niger K10 by 3-cyanopyridine. The whole cell biocatalyst was active at pH 3-11 and hydrolyzed the cyano group into acid and/or amide functions in benzonitrile as well as in its meta- and para-substituted derivatives, cyanopyridines, 2-phenylacetonitrile and thiophen-2-acetonitrile. Amides constituted a significant part of the total biotransformation products of 2- and 4-cyanopyridine, 4-chlorobenzonitrile, 4-tolunitrile and 1,4-dicyanobenzene, while alpha-substituted acrylonitriles gave amides as the sole products. (C) 2004 Elsevier B.V. All rights reserved.

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页码：227 / 232

页数：6

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