Clathrin-mediated endocytosis and Alzheimer's disease: An update

被引：83

作者：

Wu, Fangbai ^{[1
]}

Yao, Pamela J. ^{[1
]}

机构：

[1] NIA, Neurosci Lab, NIH, Biomed Res Ctr, Baltimore, MD 21224 USA

来源：

AGEING RESEARCH REVIEWS | 2009年 / 8卷 / 03期

关键词：

Alzheimer's disease; Endocytosis; Clathrin; APP processing; AMYLOID PRECURSOR PROTEIN; COATED VESICLES; SYNAPTIC VESICLE; IN-VIVO; ASSEMBLY PROTEIN; NUMB; CELL; PATHOGENESIS; TRAFFICKING; EXPRESSION;

D O I：

10.1016/j.arr.2009.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Thanks to new evidence we are now a step closer to understanding how neurons produce amyloid-beta peptide (A beta)-the chief culprit of Alzheimer's disease. As importance of clathrin-mediated endocytosis to normal neurons has become clearer, so has its role in pathology of neurological disorders. Here we update recent evidence that endocytosis plays a central role in the production of A beta in neurons. Published by Elsevier Ireland Ltd.

引用

页码：147 / 149

页数：3

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