Modulation of gene expression by alloimmune networks following murine heart transplantation

被引：5

作者：

Christopher, K

Mueller, TF

Liang, Y

Finn, PW

Perkins, DL

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Renal Div,Lab Mol Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Pulm Div, Boston, MA 02115 USA

来源：

MOLECULAR GENETICS AND GENOMICS | 2004年 / 271卷 / 06期

关键词：

graft survival; dendrograms; transgenic mouse strains; algorithms; self-organizing maps;

D O I：

10.1007/s00438-004-1013-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of our study was to analyze gene expression profiles in a complex in vivo model of solid organ transplantation, and to investigate the effects of single-gene deletions on alloimmunity. Using algorithms to generate dendrograms and self-organizing maps, we differentiated the alloimmune profiles of 16 transgenic knockout mouse strains, and identified subsets of genes that correlate with the duration of graft survival and provide candidates for prognostic and diagnostic indicators following transplantation in our model system.

引用

页码：687 / 696

页数：10

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[1] Topology of evolving networks:: Local events and universality [J].