Human milk glycoproteins inhibit the adherence of Salmonella typhimurium to HeLa cells

被引：32

作者：

Bessler, Heidi Christina ^{[1
]}

de Oliveira, Inaiara Rosa ^{[1
]}

Giugliano, Loreny Gimenes ^{[1
]}

机构：

[1] Univ Brasilia, Inst Ciencias Biol, Dept Biol Celular, Microbiol Lab, BR-70910900 Brasilia, DF, Brazil

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2006年 / 50卷 / 11期

关键词：

diarrhea; human milk; glycoproteins; Salmonella typhimurium;

D O I：

10.1111/j.1348-0421.2006.tb03863.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of human milk, as well as its protein fractions, to inhibit the adhesion and invasion of Salmonella typhimurium to HeLa cells was investigated. The results revealed that milk secretory immunoglobulin A (sIgA) inhibited neither the adherence nor the bacterial invasion; however, free secretory component and lactoferrin inhibited the bacterial adhesion and interacted with several bacterial proteins. Our data indicated that glycoproteins such as free secretory component and lactoferrin could act as protective compounds against infant enteric diseases, possibly binding to bacterial surface and blocking adhesion, the primordial step of S. typhimurium infection.

引用

页码：877 / 882

页数：6

共 26 条

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