Blocking and tackling HIV

被引：3

作者：

Haigwood, Nancy L. ^{[1
]}

Hirsch, Vanessa M. ^{[2
]}

机构：

[1] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR USA

[2] NIAID, US Natl Inst Hlth, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 08期

关键词：

NEUTRALIZING ANTIBODIES; VIRUS; PLASMA;

D O I：

10.1038/nm0809-841

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two studies suggest that low levels of antibodies, when present continuously, effectively limit or prevent HIV infection (pages 951-954 and 901-906). The findings provide hope for the development of a vaccine.

引用

页码：841 / 842

页数：2

共 12 条

[1] Frequency and Phenotype of Human Immunodeficiency Virus Envelope-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies [J].

Doria-Rose, Nicole A. ;

Klein, Rachel M. ;

Manion, Maura M. ;

O'Dell, Sijy ;

Phogat, Adhuna ;

Chakrabarti, Bimal ;

Hallahan, Claire W. ;

Migueles, Stephen A. ;

Wrammert, Jens ;

Ahmed, Rafi ;

Nason, Martha ;

Wyatt, Richard T. ;

Mascola, John R. ;

Connors, Mark .

JOURNAL OF VIROLOGY, 2009, 83 (01) :188-199

[2] Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies [J].

Haigwood, NL ;

Montefiori, DC ;

Sutton, WF ;

McClure, J ;

Watson, AJ ;

Voss, G ;

Hirsch, VM ;

Richardson, BA ;

Letvin, NL ;

Hu, SL ;

Johnson, PR .

JOURNAL OF VIROLOGY, 2004, 78 (11) :5983-5995

[3] Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques [J].

Hessell, Ann J. ;

Poignard, Pascal ;

Hunter, Meredith ;

Hangartner, Lars ;

Tehrani, David M. ;

Bleeker, Wim K. ;

Parren, Paul W. H. I. ;

Marx, Preston A. ;

Burton, Dennis R. .

NATURE MEDICINE, 2009, 15 (08) :951-U155

[4] Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers [J].

Hessell, Ann J. ;

Rakasz, Eva G. ;

Poignard, Pascal ;

Hangartner, Lars ;

Landucci, Gary ;

Forthal, Donald N. ;

Koff, Wayne C. ;

Watkins, David I. ;

Burton, Dennis R. .

PLOS PATHOGENS, 2009, 5 (05)

[5] Human immunodeficiency virus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma [J].

Igarashi, T ;

Brown, C ;

Azadegan, A ;

Haigwood, N ;

Dimitrov, D ;

Martin, MA ;

Shibata, R .

NATURE MEDICINE, 1999, 5 (02) :211-216

[6] Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys [J].

Johnson, Philip R. ;

Schnepp, Bruce C. ;

Zhang, Jianchao ;

Connell, Mary J. ;

Greene, Sean M. ;

Yuste, Eloisa ;

Desrosiers, Ronald C. ;

Clark, K. Reed .

NATURE MEDICINE, 2009, 15 (08) :901-U99

[7] Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals [J].

Li, Yuxing ;

Svehla, Krisha ;

Louder, Mark K. ;

Wycuff, Diane ;

Phogat, Sanjay ;

Tang, Min ;

Migueles, Stephen A. ;

Wu, Xueling ;

Phogat, Adhuna ;

Shaw, George M. ;

Connors, Mark ;

Hoxie, James ;

Mascola, John R. ;

Wyatt, Richard .

JOURNAL OF VIROLOGY, 2009, 83 (02) :1045-1059

[8] Continuous Viral Escape and Selection by Autologous Neutralizing Antibodies in Drug-Naive Human Immunodeficiency Virus Controllers [J].

Mahalanabis, Madhumita ;

Jayaraman, Pushpa ;

Miura, Toshiyuki ;

Pereyra, Florencia ;

Chester, E. Michael ;

Richardson, Barbra ;

Walker, Bruce ;

Haigwood, Nancy L. .

JOURNAL OF VIROLOGY, 2009, 83 (02) :662-672

[9] Determination of a statistically valid neutralization titer in plasma that confers protection against simian-human immunodeficiency virus challenge following passive transfer of high-titered neutralizing antibodies [J].

Nishimura, Y ;

Igarashi, T ;

Haigwood, N ;

Sadjadpour, R ;

Plishka, RJ ;

Buckler-White, A ;

Shibata, R ;

Martin, MA .

JOURNAL OF VIROLOGY, 2002, 76 (05) :2123-2130

[10] Factors Associated with the Development of Cross-Reactive Neutralizing Antibodies during Human Immunodeficiency Virus Type 1 Infection [J].

Sather, D. Noah ;

Armann, Jakob ;

Ching, Lance K. ;

Mavrantoni, Angeliki ;

Sellhorn, George ;

Caldwell, Zachary ;

Yu, Xuesong ;

Wood, Blake ;

Self, Steve ;

Kalams, Spyros ;

Stamatatos, Leonidas .

JOURNAL OF VIROLOGY, 2009, 83 (02) :757-769

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