Effect of selected triterpenoids on chronic dermal inflammation

被引：96

作者：

Manez, S ^{[1
]}

Recio, MC ^{[1
]}

Giner, RM ^{[1
]}

Rios, JL ^{[1
]}

机构：

[1] UNIV VALENCIA,DEPT FARMACOL,E-46100 BURJASSOT,SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 334卷 / 01期

关键词：

inflammation; chronic; skin; 12-O-tetradecanoylphorbol-13-acetate; triterpenoids;

D O I：

10.1016/S0014-2999(97)01187-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The activity of four natural triterpenoids on a 12-O-tetradecanoylphorbol-13-acetate multiple-dose model of skin chronic inflammation was studied. Erythrodiol and ursolic acid were significantly effective. The most important features concerning structure-activity relationship and previous data on the effect of these triterpenoids on other inflammatory conditions are discussed. (C) 1997 Elsevier Science B.V.

引用

页码：103 / 105

页数：3

共 12 条

[1] COMPARATIVE HISTOMORPHOMETRIC CHANGES IN SENCAR MOUSE EPIDERMIS IN RESPONSE TO MULTIPLE TREATMENTS WITH COMPLETE AND STAGE-SPECIFIC TUMOR PROMOTING AGENTS [J].