RNA interference as potential therapy - Not so fast.

被引：22

作者：

Marsden, Philip A.

机构：

[1] St Michaels Hosp, Div Nephrol, Toronto, ON M5B 1W8, Canada

[2] Univ Toronto, Toronto, ON, Canada

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2006年 / 355卷 / 09期

关键词：

D O I：

10.1056/NEJMcibr063864

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：953 / 954

页数：2

共 4 条

[1] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

[2] Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways [J].

Grimm, Dirk ;

Streetz, Konrad L. ;

Jopling, Catherine L. ;

Storm, Theresa A. ;

Pandey, Kusum ;

Davis, Corrine R. ;

Marion, Patricia ;

Salazar, Felix ;

Kay, Mark A. .

NATURE, 2006, 441 (7092) :537-541

[3] Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets [J].

Lewis, BP ;

Burge, CB ;

Bartel, DP .

CELL, 2005, 120 (01) :15-20

[4] Control of translation and mRNA degradation by miRNAs and siRNAs [J].

Valencia-Sanchez, MA ;

Liu, JD ;

Hannon, GJ ;

Parker, R .

GENES & DEVELOPMENT, 2006, 20 (05) :515-524

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