How blind is double-blind? A study of fish oil versus placebo

被引：13

作者：

Damico, KE

Stoll, AL

Marangell, LB

Cohen, BM

机构：

[1] McLean Hosp, Ctr Dev Novel & Natural Treatments Mood Disorders, Psychopharmacol Res Lab, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[3] Baylor Coll Med, Dept Psychiat, Houston, TX 77030 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2002年 / 66卷 / 04期

关键词：

D O I：

10.1054/plef.2002.0364

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The distinctive aftertaste associated with fish oil preparations used in clinical trials of omega-3 fatty acids may weaken the double-blind. This double-blind pilot study was designed to examine whether normal subjects could correctly 'guess' if they were receiving capsules containing concentrated fish oil or capsules of pure olive oil. The informed consent was designed to give subjects ambiguous expectations about what oil they might be receiving to examine whether this would influence their guess. Despite a marked difference in taste experience, there was no significant difference incorrect guesses between the two groups. The results suggest that altering subjects' expectations could further improve the validity of the double-blind. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：393 / 395

页数：3

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