Medium-dependent electron and H atom transfer between 2′-deoxyadenosine and menadione:: A magnetic field effect study

被引：36

作者：

Sengupta, T ^{[1
]}

Choudhury, SD ^{[1
]}

Basu, S ^{[1
]}

机构：

[1] Saha Inst Nucl Phys, Div Chem Sci, Kolkata 700064, W Bengal, India

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 34期

关键词：

D O I：

10.1021/ja0490976

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interaction between 2'-deoxyadenosine and the model antitumor drug menadione has been studied in organic solvent and in micellar medium. The aim of the work is to elucidate the mechanism of this drug-nucleoside interaction and to determine the environmental effects. Laser flash photolysis and magnetic field effect are used to detect the transients and their spin states. The results indicate that H atom transfer and electron transfer are the operative mechanisms depending upon the medium.

引用

页码：10589 / 10593

页数：5

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