MCM-41 heterogenized chiral amines as base catalysts for enantio selective Michael reaction

被引：35

作者：

Corma, A

Iborra, S

Rodríguez, I

Iglesias, M

Sánchez, F

机构：

[1] Univ Politecn Valencia, CSIC, Inst Tecnol Quim, Valencia 46022, Spain

[2] CSIC, Inst Quim Organ, E-28006 Madrid, Spain

来源：

CATALYSIS LETTERS | 2002年 / 82卷 / 3-4期

关键词：

enantioselective Michael reaction; MCM-41 heterogenized cinchonine; heterogenized cinchonidine; solid chiral base catalyst; enantioselective catalysts;

D O I：

10.1023/A:1020531315091

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Cinchonidine and cinchonine have been grafted onto pure silica MCM-41. It has been shown that both supported alkaloids are active catalysts for the Michael addition of ethyl 2-oxocyclopentanecarboxylate and methyl vinyl ketone, anchored cinchonidine being more active and enantioselective than anchored cinchonine. The study of the influence of the polarity of the solvent and reaction temperature on the optical induction shows that there is not a direct correlation between solvent polarity and enantioselectivity, and the maximum optical yield was obtained between 278 and 273 K.

引用

页码：237 / 242

页数：6

共 48 条

[1] Best design of heterogenized β-aminoalcohols for improvement of enantioselective addition of diethylzinc to benzaldehyde [J].