Synthesis of α-amino acid derivatives and amines via activation of simple alkyl halides by zinc in water

被引：47

作者：

Huang, T ^{[1
]}

Keh, CCK ^{[1
]}

Li, CJ ^{[1
]}

机构：

[1] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 20期

关键词：

D O I：

10.1039/b204585k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the synthesis of alpha-amino acid derivatives and amines is developed via a zinc-mediated conjugate addition reaction of alkyl halides to alpha-phthalimidoacrylate derivatives and nucleophilic addition to imines in the presence of NH4Cl in water. No reaction was observed in the absence of water.

引用

页码：2440 / 2441

页数：2

共 22 条

[1]

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[2]

BURK MJ, 1998, CHEMTRACTS ORG CHEM, V11, P787

[3]

CHAN TH, 1996, PURE APPL CHEM, V52, P5643

[4] RECENT DEVELOPMENTS IN THE STEREOSELECTIVE SYNTHESIS OF ALPHA-AMINO-ACIDS [J].