Lariatins, antimycobacterial peptides produced by Rhodococcus sp K01-B0171, have a lasso structure

被引：116

作者：

Iwatsuki, Masato

Tomoda, Hiroshi

Uchida, Ryuji

Gouda, Hiroaki

Hirono, Shuichi ^{[1
]}

Omura, Satoshi

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 108, Japan

[2] Kitasato Univ, Kitasato Inst, Minato Ku, Tokyo 108, Japan

[3] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 108, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 23期

关键词：

D O I：

10.1021/ja056780z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two antimycobacterial agents, lariatins A and B, were isolated from the culture broth of Rhodococcus sp. K01-B0171. Their structures were elucidated by spectral analysis and advanced protein chemical methods to be unique cyclic peptides, which consist of 18 and 20 L-amino acid residues with an internal linkage between the gamma-carboxyl group of Glu8 and the alpha-amino group of Gly1. The three-dimensional structure of lariatin A deduced from NMR data by dynamical simulated annealing method indicates that the tail segment ( Trp9-Pro18) passes through the ring segment ( Gly1-Glu8) to form a 'lasso' structure.

引用

页码：7486 / 7491

页数：6

共 32 条

[1] Foreword from the co-editor-in-chief [J].

Brennan, PJ .

TUBERCULOSIS, 2001, 81 (1-2) :1-1

[2] MLEV-17-BASED TWO-DIMENSIONAL HOMONUCLEAR MAGNETIZATION TRANSFER SPECTROSCOPY [J].

BAX, A ;

DAVIS, DG .

JOURNAL OF MAGNETIC RESONANCE, 1985, 65 (02) :355-360

[3] PRACTICAL ASPECTS OF TWO-DIMENSIONAL TRANSVERSE NOE SPECTROSCOPY [J].

BAX, A ;

DAVIS, DG .

JOURNAL OF MAGNETIC RESONANCE, 1985, 63 (01) :207-213

[4] Structure of antibacterial peptide microcin J25: A 21-residue lariat protoknot [J].

Bayro, MJ ;

Mukhopadhyay, J ;

Swapna, GVT ;

Huang, JY ;

Ma, LC ;

Sineva, E ;

Dawson, PE ;

Montelione, GT ;

Ebright, RH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (41) :12382-12383

[5]

Brunger AT, 1993, XPLOR MANUAL VERSION

[6]

CHANG CD, 1978, INT J PEPT PROT RES, V11, P246

[7] Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [J].

Cole, ST ;

Brosch, R ;

Parkhill, J ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Gordon, SV ;

Eiglmeier, K ;

Gas, S ;

Barry, CE ;

Tekaia, F ;

Badcock, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, R ;

Devlin, K ;

Feltwell, T ;

Gentles, S ;

Hamlin, N ;

Holroyd, S ;

Hornby, T ;

Jagels, K ;

Krogh, A ;

McLean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Osborne, J ;

Quail, MA ;

Rajandream, MA ;

Rogers, J ;

Rutter, S ;

Seeger, K ;

Skelton, J ;

Squares, R ;

Squares, S ;

Sulston, JE ;

Taylor, K ;

Whitehead, S ;

Barrell, BG .

NATURE, 1998, 393 (6685) :537-+

[8] SOLUTION STRUCTURE OF RP-71955, A NEW 21 AMINO-ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS [J].

FRECHET, D ;

GUITTON, JD ;

HERMAN, F ;

FAUCHER, D ;

HELYNCK, G ;

DUSORBIER, BM ;

RIDOUX, JP ;

JAMESSURCOUF, E ;

VUILHORGNE, M .

BIOCHEMISTRY, 1994, 33 (01) :42-50

[9] 3-DIMENSIONAL SOLUTION STRUCTURE OF THE B-DOMAIN OF STAPHYLOCOCCAL PROTEIN-A - COMPARISONS OF THE SOLUTION AND CRYSTAL-STRUCTURES [J].

GOUDA, H ;

TORIGOE, H ;

SAITO, A ;

SATO, M ;

ARATA, Y ;

SHIMADA, I .

BIOCHEMISTRY, 1992, 31 (40) :9665-9672

[10] PRACTICAL ASPECTS OF THE E-COSY TECHNIQUE - MEASUREMENT OF SCALAR SPIN SPIN COUPLING-CONSTANTS IN PEPTIDES [J].

GRIESINGER, C ;

SORENSEN, OW ;

ERNST, RR .

JOURNAL OF MAGNETIC RESONANCE, 1987, 75 (03) :474-492

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