Potentiometric flow injection determination of serum bromide in patients with epilepsy

被引：13

作者：

Katsu, T ^{[1
]}

Mori, Y ^{[1
]}

Matsuka, N ^{[1
]}

Gomita, Y ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT HOSP PHARM,OKAYAMA 700,JAPAN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1997年 / 15卷 / 12期

关键词：

flow injection analysis; ion-selective electrode; bromide; therapeutic drug monitoring; epilepsy;

D O I：

10.1016/S0731-7085(96)02017-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A flow injection system was constructed using a bromide-selective electrode and used to determine serum bromide in patients with epilepsy. A 10-mu l serum sample was injected into a carrier stream flowing at 0.12 mi min(-1). Potential changes and bromide concentrations were linearly related in the range 3-50 mM. The lower limit of detection for serum bromide was 1 mM and this electrode sensitivity spanned the entire concentration range required for bromide therapy (9-24 mM). The results compared favourably with those obtained by colorimetry. (C) 1997 Elsevier Science B.V.

引用

页码：1829 / 1832

页数：4

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