Optically programmable assembly of ordered bead arrays: A novel technology for on-chip biochemical analysis

被引：3

作者：

Chau, C ^{[1
]}

Banerjee, S ^{[1
]}

Seul, M ^{[1
]}

机构：

[1] BioArray Solut LLC, Piscataway, NJ 08854 USA

来源：

MICROFLUIDIC DEVICES AND SYSTEMS II | 1999年 / 3877卷

关键词：

D O I：

10.1117/12.359352

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

We describe an optically programmable bead array assembly process and its efficient implementation Invoking our core technology of Light-controlled Electrokinetic Assembly of Particles near Surfaces (LEAPS), this process enables the on-demand assembly and real-time manipulation of planar arrays of microparticles ("beads") within a small reaction chamber in response to electric fields and in accordance with computer-generated patterns of illumination. We are integrating this array fabrication process with proprietary microfluidics and image acquisition in a palmtop bioanalytical microlab to provide a general-purpose platform for a highly parallel assay format in which tens to thousands of biochemical tests "assays") can be performed simultaneously on the surface of a semiconductor chip. Applications include the quantitative analysis of protein-protein interactions and DNA hybridization as well as cellular analysis.

引用

页码：36 / 42

页数：7

共 9 条

[1] Preparation and hybridization analysis of DNA/RNA from E-coli on microfabricated bioelectronic chips [J].