A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels

被引：855

作者：

Inagaki, N

Gonoi, T

Clement, JP

Wang, CZ

AguilarBryan, L

Bryan, J

Seino, S

机构：

[1] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CHUO KU,CHIBA 260,JAPAN

[2] BAYLOR COLL MED,DEPT CELL BIOL,HOUSTON,TX 77030

[3] BAYLOR COLL MED,DEPT MED,HOUSTON,TX 77030

来源：

NEURON | 1996年 / 16卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0896-6273(00)80124-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6.2 in COS1 cells reconstitutes the properties of K-ATP channels described in cardiac and skeletal muscle. The SUR2/Kir6.2 channel is less sensitive than the SUR/Kir6.2 channel (the pancreatic beta cell K-ATP channel) to both ATP and the sulfonylurea glibenclamide and is activated by the cardiac K-ATP channel openers, cromakalim and pinacidil, but not by diazoxide. In addition, SUR2 binds glibenclamide with lower affinity. The present study shows that the ATP sensitivity and pharmacological properties of K-ATP channels are determined by a family of structurally related but functionally distinct sulfonylurea receptors.

引用

收藏

页码：1011 / 1017

页数：7

相关论文

共 34 条

[1]

AGUILARBRYAN L, 1990, J BIOL CHEM, V265, P8218

[2] CLONING OF THE BETA-CELL HIGH-AFFINITY SULFONYLUREA RECEPTOR - A REGULATOR OF INSULIN-SECRETION [J].

AGUILARBRYAN, L ;

NICHOLS, CG ;

WECHSLER, SW ;

CLEMENT, JP ;

BOYD, AE ;

GONZALEZ, G ;

HERRERASOSA, H ;

NGUY, K ;

BRYAN, J ;

NELSON, DA .

SCIENCE, 1995, 268 (5209) :423-426

[3] Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels [J].

Ammala, C ;

Moorhouse, A ;

Gribble, F ;

Ashfield, R ;

Proks, P ;

Smith, PA ;

Sakura, H ;

Coles, B ;

Ashcroft, SJH ;

Ashcroft, FM .

NATURE, 1996, 379 (6565) :545-548

[4] ADENOSINE 5'-TRIPHOSPHATE-SENSITIVE POTASSIUM CHANNELS [J].

ASHCROFT, FM .

ANNUAL REVIEW OF NEUROSCIENCE, 1988, 11 :97-118

[5] ADENOSINE-5'-TRIPHOSPHATE-SENSITIVE ION CHANNELS IN NEONATAL RAT CULTURED CENTRAL NEURONS [J].

ASHFORD, MLJ ;

STURGESS, NC ;

TROUT, NJ ;

GARDNER, NJ ;

HALES, CN .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1988, 412 (03) :297-304

[6] CHARACTERIZATION, PURIFICATION, AND AFFINITY LABELING OF THE BRAIN [H-3] GLIBENCLAMIDE-BINDING PROTEIN, A PUTATIVE NEURONAL ATP-REGULATED K+ CHANNEL [J].

BERNARDI, H ;

FOSSET, M ;

LAZDUNSKI, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9816-9820

[7] INTRACELLULAR ATP DIRECTLY BLOCKS K+ CHANNELS IN PANCREATIC B-CELLS [J].

COOK, DL ;

HALES, CN .

NATURE, 1984, 311 (5983) :271-273

[8] ATP-DEPENDENT POTASSIUM CHANNELS OF MUSCLE-CELLS - THEIR PROPERTIES, REGULATION, AND POSSIBLE FUNCTIONS [J].

DAVIES, NW ;

STANDEN, NB ;

STANFIELD, PR .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1991, 23 (04) :509-535

[9] THE POTASSIUM CHANNEL OPENER CROMAKALIM (BRL-34915) ACTIVATES ATP-DEPENDENT K+ CHANNELS IN ISOLATED CARDIAC MYOCYTES [J].

ESCANDE, D ;

THURINGER, D ;

LEGUERN, S ;

CAVERO, I .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (02) :620-625

[10] POTASSIUM CHANNEL OPENERS ACT THROUGH AN ACTIVATION OF ATP-SENSITIVE K+ CHANNELS IN GUINEA-PIG CARDIAC MYOCYTES [J].

ESCANDE, D ;

THURINGER, D ;

LEGUERN, S ;

COURTEIX, J ;

LAVILLE, M ;

CAVERO, I .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1989, 414 (06) :669-675

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