Design of sequence-specific DNA-binding ligands

被引：45

作者：

Nielsen, PE

机构：

[1] Center for Biomolecular Recognition, Dept. for Biochemistry and Genetics, Panum Institute, DK-2200 N Copenhagen

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 1997年 / 3卷 / 04期

关键词：

DNA recognition; triplexes; molecular recognition; peptide nucleic acids;

D O I：

10.1002/chem.19970030404

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double-stranded DNA can be viewed as a multifunctional, modular receptor that can be read sequence-selectively in a digital way (base pair per base pair) by a complementary, similarly modular ligand. This principle has been exploited in several approaches to design sequence-specific DNA-binding ligands, such as triplex-forming oligonucleotides, peptide nucleic acids and minor groove binding polyamides.

引用

页码：505 / 508

页数：4

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