Phantom limb pain: a case of maladaptive CNS plasticity?

被引：627

作者：

Flor, Herta ^{[1
]}

Nikolajsen, Lone

Jensen, Troels Staehelin

机构：

[1] Heidelberg Univ, Cent Inst Mental Hlth, Dept Clin & Cognit Neurosci, D-68159 Mannheim, Germany

[2] Aarhus Univ Hosp, Dept Anesthesiol, DK-8000 Aarhus C, Denmark

[3] Aarhus Univ Hosp, Danish Pain Res Ctr, DK-8000 Aarhus C, Denmark

[4] Aarhus Univ Hosp, Dept Neurol, DK-8000 Aarhus C, Denmark

来源：

NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 11期

关键词：

D O I：

10.1038/nrn1991

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Phantom pain refers to pain in a body part that has been amputated or deafferented. It has often been viewed as a type of mental disorder or has been assumed to stem from pathological alterations in the region of the amputation stump. In the past decade, evidence has accumulated that phantom pain might be a phenomenon of the CNS that is related to plastic changes at several levels of the neuraxis and especially the cortex. Here, we discuss the evidence for putative pathophysiological mechanisms with an emphasis on central, and in particular cortical, changes. We cite both animal and human studies and derive suggestions for innovative interventions aimed at alleviating phantom pain.

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页码：873 / 881

页数：9

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