Stem Cell Therapies in Clinical Trials: Progress and Challenges

被引：1309

作者：

Trounson, Alan ^{[1
]}

McDonald, Courtney ^{[1
]}

机构：

[1] Hudson Inst Med Res, Clayton, Vic 3168, Australia

来源：

CELL STEM CELL | 2015年 / 17卷 / 01期

关键词：

VERSUS-HOST-DISEASE; MESENCHYMAL STROMAL CELLS; AMYOTROPHIC-LATERAL-SCLEROSIS; STEROID-REFRACTORY ACUTE; BONE-MARROW-CELLS; PHASE-I; DOUBLE-BLIND; MULTIPLE-SCLEROSIS; CROHNS-DISEASE; TRANSENDOCARDIAL INJECTION;

D O I：

10.1016/j.stem.2015.06.007

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Clinical investigations using stem cell products in regenerative medicine are addressing a wide spectrum of conditions using a variety of stem cell types. To date, there have been few reports of safety issues arising from autologous or allogeneic transplants. Many cells administered show transient presence for a few days with trophic influences on immune or inflammatory responses. Limbal stem cells have been registered as a product for eye burns in Europe and mesenchymal stem cells have been approved for pediatric graft versus host disease in Canada and New Zealand. Many other applications are progressing in trials, some with early benefits to patients.

引用

页码：11 / 22

页数：12

共 105 条

[1]

Fetal-cell revival for Parkinson's [J].

Abbott, Alison .

NATURE, 2014, 510 (7504) :195-196

[2]

Neural Stem Cell-Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies [J].

Aboody, Karen S. ;

Najbauer, Joseph ;

Metz, Marianne Z. ;

D'Apuzzo, Massimo ;

Gutova, Margarita ;

Annala, Alexander J. ;

Synold, Timothy W. ;

Couture, Larry A. ;

Blanchard, Suzette ;

Moats, Rex A. ;

Garcia, Elizabeth ;

Aramburo, Soraya ;

Valenzuela, Valerie V. ;

Frank, Richard T. ;

Barish, Michael E. ;

Brown, Christine E. ;

Kim, Seung U. ;

Badie, Behnam ;

Portnow, Jana .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (184)

[3]

Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].

Aboody, KS ;

Brown, A ;

Rainov, NG ;

Bower, KA ;

Liu, SX ;

Yang, W ;

Small, JE ;

Herrlinger, U ;

Ourednik, V ;

Black, PM ;

Breakefield, XO ;

Snyder, EY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851

[4]

Mesenchymal Precursor Cells as Adjunctive Therapy in Recipients of Contemporary Left Ventricular Assist Devices [J].

Ascheim, Deborah D. ;

Gelijns, Annetine C. ;

Goldstein, Daniel ;

Moye, Lemuel A. ;

Smedira, Nicholas ;

Lee, Sangjin ;

Klodell, Charles T. ;

Szady, Anita ;

Parides, Michael K. ;

Jeffries, Neal O. ;

Skerrett, Donna ;

Taylor, Doris A. ;

Rame, Eduardo ;

Milano, Carmelo ;

Rogers, Joseph G. ;

Lynch, Janine ;

Dewey, Todd ;

Eichhorn, Eric ;

Sun, Benjamin ;

Feldman, David ;

Simari, Robert ;

O'Gara, Patrick T. ;

Taddei-Peters, Wendy C. ;

Miller, Marissa A. ;

Naka, Yoshifumi ;

Bagiella, Emilia ;

Rose, Eric A. ;

Woo, Y. Joseph .

CIRCULATION, 2014, 129 (22) :2287-+

[5]

Developing Stem Cell Therapies for Parkinson's Disease: Waiting Until the Time Is Right [J].

Barker, Roger A. .

CELL STEM CELL, 2014, 15 (05) :539-542

[6]

Cardiopoietic Stem Cell Therapy in Heart Failure [J].

Bartunek, Jozef ;

Behfar, Atta ;

Dolatabadi, Dariouch ;

Vanderheyden, Marc ;

Ostojic, Miodrag ;

Dens, Jo ;

El Nakadi, Badih ;

Banovic, Marko ;

Beleslin, Branko ;

Vrolix, Mathias ;

Legrand, Victor ;

Vrints, Christian ;

Vanoverschelde, Jean Louis ;

Crespo-Diaz, Ruben ;

Homsy, Christian ;

Tendera, Michal ;

Waldman, Scott ;

Wijns, William ;

Terzic, Andre .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (23) :2329-2338

[7]

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation [J].

Bernardo, Maria Ester ;

Fibbe, Willem E. .

CELL STEM CELL, 2013, 13 (04) :392-402

[8]

Bersenev A., 2015, CELLTRIALS BLOG 0122

[9]

"Mesenchymal" Stem Cells [J].

Bianco, Paolo .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :677-704

[10]

Bonab MM, 2012, CURR STEM CELL RES T, V7, P407

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