Liver enzyme activity and body mass index

被引:33
作者
Burns, CJ
Boswell, JM
Olsen, GW
机构
[1] Dow Chemical Company, Midland, MI
[2] Dow Chemical Company, Epidemiology, 1803 Building, Midland
关键词
D O I
10.1097/00043764-199612000-00010
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Obesity has been identified as a risk factor for liver disease in a number of cross-sectional studies. We investigated the association of biochemical liver tests (BLTs) among male employees of The Bow Chemical Company who had participated in two consecutive health surveillance examinations. The activity of three liver enzymes - alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transferase - were used as measures of liver injury. Body mass index was strongly associated with increased enzyme activity in both examinations. Alcohol consumption was similarly associated with each BLT after controlling for alcohol consumption, race, and age. When changes in the BLTs were investigated over time, the employees who gained weight showed a significant increase in alanine aminotransferase activity compared with those who did not gain weight.
引用
收藏
页码:1248 / 1252
页数:5
相关论文
共 12 条
  • [1] BIZZARO N, 1992, ITAL J GASTROENTEROL, V24, P237
  • [2] Haley N J, 1995, Stat Bull Metrop Insur Co, V76, P2
  • [3] LIVER-INJURY TESTS IN HAZARDOUS-WASTE WORKERS - THE ROLE OF OBESITY
    HODGSON, MJ
    VANTHIEL, DH
    LAUSCHUS, K
    KARPF, M
    [J]. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1989, 31 (03) : 238 - 242
  • [4] LIVER-DISEASE ASSOCIATED WITH EXPOSURE TO 1,1,1-TRICHLOROETHANE
    HODGSON, MJ
    HEYL, AE
    VANTHIEL, DH
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1989, 149 (08) : 1793 - 1798
  • [5] HORNBOLL P, 1982, ACTA PATH MICRO IM A, V90, P199
  • [6] MOKSHAGUNDAM S, 1995, GASTROENTEROLOGY, V108, pA1125
  • [7] OLSEN GW, 1991, J OCCUP ENVIRON MED, V33, P998
  • [8] EFFECT OF BODY-MASS AND OTHER FACTORS ON SERUM LIVER-ENZYME LEVELS IN MEN ATTENDING FOR WELL POPULATION SCREENING
    ROBINSON, D
    WHITEHEAD, TP
    [J]. ANNALS OF CLINICAL BIOCHEMISTRY, 1989, 26 : 393 - 400
  • [9] SALVAGGIO A, 1991, CLIN CHEM, V37, P720
  • [10] US Census Bureau, 1994, STAT ABSTR US