The Association Between the Cardio-ankle Vascular Index and Other Parameters of Vascular Structure and Function in Caucasian Adults: MARK Study

被引:33
作者
Gomez-Sanchez, Leticia [1 ]
Garcia-Ortiz, Luis [1 ,2 ,3 ]
Patino-Alonso, Maria C. [1 ,4 ]
Recio-Rodriguez, Jose I. [1 ,2 ]
Frontera, Guillermo [5 ]
Ramos, Rafel [6 ,7 ,8 ]
Marti, Ruth [6 ,8 ]
Agudo-Conde, Cristina [1 ,2 ]
Rodriguez-Sanchez, Emiliano [1 ,2 ,3 ]
Maderuelo-Fernandez, Jose A. [1 ,2 ]
Gomez-Marcos, Manuel A. [1 ,2 ,3 ]
机构
[1] Alamedilla Hlth Ctr, Primary Care Res Unit, Salamanca, Spain
[2] Castilla & Leon Hlth Serv SACYL Salamanca, Salamanca, Spain
[3] Univ Salamanca, Dept Med, E-37008 Salamanca, Spain
[4] Univ Salamanca, Dept Stat, E-37008 Salamanca, Spain
[5] CS G Corsaib, Primare Care Ibsalut, Palma Of Mallorca, Spain
[6] Girona Jordi Gol Inst Primary Care Res IDIAP Jord, Family Med, Res Unit, Girona, Spain
[7] Univ Girona, Sch Med, Dept Med Sci, Trans Res Grp, Girona, Spain
[8] Dr Trueta Univ Hosp, Girona Biomed Res Inst IDIBGI, Catalonia, Spain
关键词
Cardio-ankle vascular index (CAVI); Vascular structure; Vascular function; Cardiovascular risk; CORONARY-HEART-DISEASE; INTIMA-MEDIA THICKNESS; PULSE-WAVE VELOCITY; MOBIL-O-GRAPH; ARTERIAL STIFFNESS; CARDIOVASCULAR RISK; CAVI; HYPERTENSION; ARTERIOSCLEROSIS; ATHEROSCLEROSIS;
D O I
10.5551/jat.28035
中图分类号
R6 [外科学];
学科分类号
100210 [外科学];
摘要
Aim: We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment. Methods: The CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham- D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk. Results: The mean value of the CAVI score was 8.59 +/- 1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p< 0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of > 0.90 mm was 8.95 (AUC=0.67) for the CAVI score, 8.85 (AUC=0.66) for cf-PWV and 15.10 (AUC=0.66) for ba-PWV. The cut-off to detect a maxima IMT of > 0.90 mm was 8.60 (AUC=0.62) for the CAVI score, 8.85 (AUC=0.64) for cf-PWV and 15.75 (AUC=0.70) for ba-PWV. Conclusion: There was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults.
引用
收藏
页码:901 / 911
页数:11
相关论文
共 42 条
[1]
Estimation of ten-year risk of fatal cardiovascular disease in Europe:: the SCORE project [J].
Conroy, RM ;
Pyörälä, K ;
Fitzgerald, AP ;
Sans, S ;
Menotti, A ;
De Backer, G ;
De Bacquer, D ;
Ducimetière, P ;
Jousilahti, P ;
Keil, U ;
Njolstad, I ;
Oganov, RG ;
Thomsen, T ;
Tunstall-Pedoe, H ;
Tverdal, A ;
Wedel, H ;
Whincup, P ;
Wilhelmsen, L ;
Graham, IM .
EUROPEAN HEART JOURNAL, 2003, 24 (11) :987-1003
[2]
General cardiovascular risk profile for use in primary care - The Framingham Heart Study [J].
D'Agostino, Ralph B. ;
Vasan, Ramachandran S. ;
Pencina, Michael J. ;
Wolf, Philip A. ;
Cobain, Mark ;
Massaro, Joseph M. ;
Kannel, William B. .
CIRCULATION, 2008, 117 (06) :743-753
[3]
Evaluation of the Mobil-O-Graph new generation ABPM device using the ESH criteria [J].
Franssen, Pascal M. L. ;
Imholz, Ben P. M. .
BLOOD PRESSURE MONITORING, 2010, 15 (04) :229-231
[4]
Protocol for Measuring Carotid Intima-Media Thickness That Best Correlates With Cardiovascular Risk and Target Organ Damage [J].
Gomez-Marcos, Manuel A. ;
Recio-Rodriguez, Jose I. ;
Patino-Alonso, Maria C. ;
Agudo-Conde, Cristina ;
Gomez-Sanchez, Leticia ;
Gomez-Sanchez, Marta ;
Rodriguez-Sanchez, Emiliano ;
Garcia-Ortiz, Luis .
AMERICAN JOURNAL OF HYPERTENSION, 2012, 25 (09) :955-961
[5]
Comparison of Atherosclerotic Indicators Between Cardio Ankle Vascular Index and Brachial Ankle Pulse Wave Velocity [J].
Horinaka, Shigeo ;
Yabe, Akihisa ;
Yagi, Hiroshi ;
Ishimura, Kimihiko ;
Hara, Hitoshi ;
Iemua, Tomoyuki ;
Matsuoka, Hiroaki .
ANGIOLOGY, 2009, 60 (04) :468-476
[6]
Relationship of Cardio-Ankle Vascular Index (CAVI) to Carotid and Coronary Arteriosclerosis [J].
Izuhara, Masayasu ;
Shioji, Keisuke ;
Kadota, Shin ;
Baba, Osamu ;
Takeuchi, Yuzo ;
Uegaito, Takashi ;
Mutsuo, Satoru ;
Matsuda, Mitsuo .
CIRCULATION JOURNAL, 2008, 72 (11) :1762-1767
[7]
Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis [J].
Kadota, Koichiro ;
Takamura, Noboru ;
Aoyagi, Kiyoshi ;
Yamasaki, Hironori ;
Usa, Toshiro ;
Nakazato, Mio ;
Maeda, Takahiro ;
Wada, Mitsuhiro ;
Nakashima, Ken-ichiro ;
Abe, Koh ;
Takeshima, Fuminao ;
Ozono, Yoshiyuki .
CIRCULATION JOURNAL, 2008, 72 (02) :304-308
[8]
Kanamoto Masafumi, 2013, J Cardiovasc Dis Res, V4, P15, DOI 10.1016/j.jcdr.2013.02.001
[9]
Cut-Off Value of Brachial-Ankle Pulse Wave Velocity to Predict Cardiovascular Disease in Hypertensive Patients: A Cohort Study [J].
Kawai, Tatsuo ;
Ohishi, Mitsuru ;
Onishi, Miyuki ;
Ito, Norihisa ;
Takeya, Yasushi ;
Maekawa, Yoshihiro ;
Rakugi, Hiromi .
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2013, 20 (04) :391-400
[10]
Associations Between Cardio-Ankle Vascular Index and Microvascular Complications in Type 2 Diabetes Mellitus Patients [J].
Kim, Kwang Joon ;
Lee, Byung-Wan ;
Kim, Hyun-min ;
Shin, Joo Youn ;
Kang, Eun Seok ;
Cha, Bong Soo ;
Lee, Eun Jig ;
Lim, Sung-Kil ;
Lee, Hyun Chul .
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2011, 18 (04) :328-336