The 3D Genome in Transcriptional Regulation and Pluripotency

被引：279

作者：

Gorkin, David U. ^{[1
]}

Leung, Danny ^{[1
]}

Ren, Bing ^{[1
,2
]}

机构：

[1] Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Cellular & Mol Med, Inst Genome Med,Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

CELL STEM CELL | 2014年 / 14卷 / 06期

关键词：

NUCLEAR LAMINA INTERACTIONS; POLYMERASE-II TRANSCRIPTION; ENHANCER-BLOCKING ACTIVITY; EMBRYONIC STEM-CELLS; LONG NONCODING RNAS; BETA-GLOBIN LOCUS; CHROMATIN INTERACTIONS; GENE-EXPRESSION; CHROMOSOME CONFORMATION; HIGH-RESOLUTION;

D O I：

10.1016/j.stem.2014.05.017

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

It can be convenient to think of the genome as simply a string of nucleotides, the linear order of which encodes an organism's genetic blueprint. However, the genome does not exist as a linear entity within cells where this blueprint is actually utilized. Inside the nucleus, the genome is organized in three-dimensional (3D) space, and lineage-specific transcriptional programs that direct stem cell fate are implemented in this native 3D context. Here, we review principles of 3D genome organization in mammalian cells. We focus on the emerging relationship between genome organization and lineage-specific transcriptional regulation, which we argue are inextricably linked.

引用

页码：762 / 775

页数：14

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