The insulin receptor substrate-1: A biomarker for cancer?

被引：53

作者：

Baserga, Renato ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2009年 / 315卷 / 05期

关键词：

Insulin; GROWTH-FACTOR-I; SIMIAN-VIRUS-40; T-ANTIGEN; NUCLEAR TRANSLOCATION; IGF-I; INSULIN-RECEPTOR-SUBSTRATE-1; IRS-1; TERMINAL SEQUENCE; TRANSFORMATION; CELL; PHOSPHORYLATION; ACTIVATION;

D O I：

10.1016/j.yexcr.2008.09.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review focuses on IRS-1 and the evidence of its role in cell transformation. The literature strongly suggests that IRS-1 Should be considered a biomaker for cancers Susceptible to IGF-IR targeting. In addition, I Would like to propose that IRS-1 may have a more general role in cancer, and could be considered as a protein having the opposite effect Of tumor Suppressors, a Sort of anti-p53 molecule. (C) 2008 Published by Elsevier Inc.

引用

页码：727 / 732

页数：6

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