Expression of A, B, C and DR antigens in definite Meniere's disease in a Spanish population

被引：15

作者：

López-Escámez, JA

López-Nevot, A

Cortes, R

Ramal, L

López-Nevot, MA

机构：

[1] Hosp Poniente, Dept Surg, Div Otorhinolaryngol, Almeria 04700, Spain

[2] Univ Hosp Virgen de las Nieves, Dept Otolaryngol, Granada, Spain

[3] Univ Hosp Virgen de las Nieves, Dept Immunol, Granada, Spain

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2002年 / 259卷 / 07期

关键词：

HLA antigens; DR antigens; vertigo; sensorineural hearing loss; inner ear; controlled studies;

D O I：

10.1007/s00405-002-0463-0

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

To analyze the associations of HLA class I and II antigens in patients with Meniere's disease (MD) in southern Spain, 54 patients with definite MD according to the diagnostic scale of the AAO-HNS were compared with 534 normal controls in a prospective multicenter study. We performed a serological typing for A, B, C and DR specificities of the major histocompatibility complex and allele-specific amplification for HLA-DRB1. No differences were found in the distribution of class I antigens or DR antigens in patients with definite MD when they were compared with the control group. Our results suggest that HLA antigens do not determine an increased susceptibility to develop MD.

引用

页码：347 / 350

页数：4

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