Self-assembling materials for therapeutic delivery

被引:378
作者
Branco, Monica C. [1 ,2 ]
Schneider, Joel P. [1 ]
机构
[1] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA
[2] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA
基金
美国国家卫生研究院;
关键词
Self-assembly; Parenteral delivery; Peptide hydrogel; Block copolymer; POLYION COMPLEX MICELLES; RESPONSIVE POLYMERIC MICELLES; 3-DIMENSIONAL CELL-CULTURE; BLOCK-COPOLYMER VESICLES; WATER-SOLUBLE DRUGS; IN-VITRO RELEASE; SUSTAINED-RELEASE; AMPHOTERICIN-B; GENE DELIVERY; ORAL BIOAVAILABILITY;
D O I
10.1016/j.actbio.2008.09.018
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A growing number of medications must be administered through parenteral delivery, i.e., intravenous, intramuscular, or subcutaneous injection, to ensure effectiveness of the therapeutic. For some therapeutics, the use of delivery vehicles in conjunction with this delivery mechanism can improve drug efficacy and patient compliance. Macromolecular self-assembly has been exploited recently to engineer materials for the encapsulation and controlled delivery of therapeutics. Self-assembled materials offer the advantages of conventional crosslinked materials normally used for release, but also provide the ability to tailor specific bulk material properties, such as release profiles, at the molecular level via monomer design. As a result, the design of materials from the "bottom up" approach has generated a variety of supramolecular devices for biomedical applications. This review provides an overview of self-assembling molecules, their resultant structures, and their use in therapeutic delivery. It highlights the current progress in the design of polymer- and peptide-based self-assembled materials. (c) 2008 Acta Materialia. Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:817 / 831
页数:15
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