High prevalence of high-level ciprofloxacin resistance in Neisseria gonorrhoeae in Tel Aviv, Israel:: Correlation with response to therapy

被引：21

作者：

Dan, M ^{[1
]}

Poch, F

Sheinberg, B

机构：

[1] E Wolfson Hosp, Infect Dis Unit, IL-58100 Holon, Israel

[2] Maccabi Hlth Serv, Cent Lab, Rishon Leziyyon, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 06期

关键词：

D O I：

10.1128/AAC.46.6.1671-1673.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A survey of the drug susceptibilities of gonococcal isolates from 100 consecutive patients attending clinics in the Tel Aviv area of Israel during the period from February to September 2000 has shown a 61% rate of ciprofloxacin resistance (MICs, greater than or equal to1 mug/ml); 51 isolates were highly resistant (MICs, greater than or equal to4 mug/ml). Ciprofloxacin-resistant strains were more prevalent among isolates with chromosomally mediated resistance to penicillin and tetracycline. Therapeutic failures with ciprofloxacin correlated with MICs of 2:1 mg/ml (P < 0.01). The high rate of ciprofloxacin resistance coinciding with a sharp rise in the incidence of gonorrhea precludes the use of fluoroquinolone drugs for the empirical treatment of gonococcal infections acquired in Israel.

引用

页码：1671 / 1673

页数：3

共 24 条

[1] Antimicrobial susceptibilities and plasmid contents of Neisseria gonorrhoeae isolates from commercial sex workers in Dhaka, Bangladesh:: Emergence of high-level resistance to ciprofloxacin [J].