Regulating cellular oxygen sensing by hydroxylation

被引：178

作者：

Fandrey, Joachim

Gorr, Thomas A.

Gassmann, Max

机构：

[1] Univ Duisburg Essen, Inst Physiol, D-45122 Essen, Germany

[2] Univ Zurich, Vetsuisse Fac, Inst Vet Physiol, CH-8057 Zurich, Switzerland

[3] Univ Zurich, ZIHP, CH-8057 Zurich, Switzerland

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 71卷 / 04期

关键词：

HIF-1; hypoxia; hypoxia-induced gene expression;

D O I：

10.1016/j.cardiores.2006.05.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oxygen homeostasis under conditions of limited O-2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O-2 sensing for adequate control of HIF-1 activation. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：642 / 651

页数：10

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