An assessment by the Statin Muscle Safety Task Force: 2014 update

被引：425

作者：

Rosenson, Robert S. ^{[1
]}

Baker, Steven K. ^{[2
]}

Jacobson, Terry A. ^{[3
]}

Kopecky, Stephen L. ^{[4
]}

Parker, Beth A. ^{[5
]}

机构：

[1] Icahn Sch Med Mt Sinai, Mt Sinai Heart, New York, NY 10029 USA

[2] McMaster Univ, Hamilton, ON, Canada

[3] Emory Univ, Atlanta, GA 30322 USA

[4] Mayo Clin, Rochester, MN USA

[5] Hartford Hosp, Henry Low Heart Ctr, Dept Cardiol, Hartford, CT 06115 USA

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2014年 / 8卷 / 03期

关键词：

Muscle adverse events; Myalgia; Myopathy; Neuromuscular testing; Rhabdomyolysis; Statin intolerance; Statins; SKELETAL-MUSCLE; CREATINE-KINASE; RISK-FACTORS; MYOPATHY; ROSUVASTATIN; ATORVASTATIN; EXERCISE; COENZYME-Q10; SIMVASTATIN; PAIN;

D O I：

10.1016/j.jacl.2014.03.004

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The National Lipid Association's Muscle Safety Expert Panel was charged with the duty of examining the definitions for statin-associated muscle adverse events, development of a clinical index to assess myalgia, and the use of diagnostic neuromuscular studies to investigate muscle adverse events. We provide guidance as to when a patient should be considered for referral to neuromuscular specialists and indications for the performance of a skeletal muscle biopsy. Based on this review of evidence, we developed an algorithm for the evaluation and treatment of patients who may be intolerant to statins as the result of adverse muscle events. The panel was composed of clinical cardiologists, clinical lipidologists, an exercise physiologist, and a neuromuscular specialist. (C) 2014 National Lipid Association. All rights reserved.

引用

页码：S58 / S71

页数：14

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