Influence of estrogen in the acquisition of intravenously self-administered heroin in female rats

被引：76

作者：

Roth, ME ^{[1
]}

Casimir, AG ^{[1
]}

Carroll, ME ^{[1
]}

机构：

[1] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2002年 / 72卷 / 1-2期

关键词：

acquisition; heroin; estradiol; estrogen; intravenous; ovariectomy; self-administration;

D O I：

10.1016/S0091-3057(01)00777-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Previous research indicates that female rats acquire cocaine and heroin self-administration at a faster rate than male rats, and female rats with endogenous estrogen, or ovariectomized (OVX) rats with estrogen replacement acquire cocaine self-administration more rapidly than female rats with estrogen either surgically or chemically blocked. The purpose of this investigation was to extend the above findings to the acquisition of heroin (0.0075 mg/kg) self-administration in female rats. An automated autoshaping procedure was used to train rats to self-administer heroin. Three groups of female rats were compared: (1) OVX + estradiol benzoate (OVX + EB), (2) OVX + vehicle (OVX + VEH), and (3) sham-operated + vehicle (SH + VEH). Results revealed that OVX + EB rats acquired heroin self-administration in significantly fewer days compared to OVX + VEH rats. Additionally, OVX + EB rats that met the acquisition criteria self-administered a significantly greater number of heroin infusion during the last 5 days of the acquisition period compared to OVX + VEH rats. These results indicate that OVX + EB rats initiate heroin use sooner than OVX + VEH rats and consume greater amounts of heroin during the last 5 days of acquisition compared to OVX + VEH female rats. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：313 / 318

页数：6

共 31 条

[1] EFFECT OF HOUSING AND GENDER ON MORPHINE SELF-ADMINISTRATION IN RATS [J].

ALEXANDER, BK ;

COAMBS, RB ;

HADAWAY, PF .

PSYCHOPHARMACOLOGY, 1978, 58 (02) :175-179

[2] Gender differences in dopaminergic function in striatum and nucleus accumbens [J].

Becker, JB .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1999, 64 (04) :803-812

[3] ESTROGEN RAPIDLY POTENTIATES AMPHETAMINE-INDUCED STRIATAL DOPAMINE RELEASE AND ROTATIONAL BEHAVIOR DURING MICRODIALYSIS [J].

BECKER, JB .

NEUROSCIENCE LETTERS, 1990, 118 (02) :169-171

[4] Acquisition of drug self-administration: Environmental and pharmacological interventions [J].

Campbell, UC ;

Carroll, ME .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2000, 8 (03) :312-325

[5] Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: Sex differences [J].

Carroll, ME ;

Campbell, UC ;

Heideman, P .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2001, 9 (03) :307-316

[6]

CARROLL ME, 1982, PHARM BIOCH BEAV, V80, P65

[7]

Chen C K, 1998, Changgeng Yi Xue Za Zhi, V21, P172

[8]

DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274

[9] Nicotine self-administration in rats: estrous cycle effects, sex differences and nicotinic receptor binding [J].

Donny, EC ;

Caggiula, AR ;

Rowell, PP ;

Gharib, MA ;

Maldovan, V ;

Booth, S ;

Mielke, MM ;

Hoffman, A ;

McCallum, S .

PSYCHOPHARMACOLOGY, 2000, 151 (04) :392-405

[10] Endogenous cholecystokinin's satiating action increases during estrus in female rats [J].

Eckel, LA ;

Geary, N .

PEPTIDES, 1999, 20 (04) :451-456

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