Acute toxicity of Orthosiphon stamineus Benth standardized extract in Sprague Dawley rats

被引：23

作者：

Abdullah, Noor Rain ^{[1
]}

Ismail, Zakiah ^{[1
]}

Ismail, Zhari ^{[2
]}

机构：

[1] Inst Med Res, Herbal Med Res Ctr, Kuala Lumpur 50588, Malaysia

[2] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia

来源：

PHYTOMEDICINE | 2009年 / 16卷 / 2-3期

关键词：

Orthosiphon stamineus; Safety profile; Acute toxicity; FLAVONOIDS;

D O I：

10.1016/j.phymed.2007.04.013

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The acute toxicity of standardized extract of Orthosiphon stamineus was studied in Sprague Dawley rats. The rats were administered a single dose of 5000 mg/kg body weight (BW) orally on Day 0 and observed for 14 days. There were no deaths recorded and the animals did not show signs of toxicity during the experimental period. The effect of the extract on general behavior, BW, food and water intake, relative organ weight per 100 g BW, hematology and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control. The acute toxicity LD50 was estimated to be > 5000 mg/kg BW. (C) 2007 Elsevier GmbH. All rights reserved.

引用

页码：222 / 226

页数：5

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