Phototoxic activity of a thiophene polyacetylene from Leuzea carthamoides

被引：24

作者：

Chobot, Vladimir

Vytlacilova, Jitka

Kubicova, Lenka

Opletal, Lubomir

Jahodar, Ludek

Laakso, Into

Vuorela, Pia

机构：

[1] Charles Univ Prague, Fac Pharm, Dept Pharmaceut Bot & Ecol, Hradec Kralove 50005, Czech Republic

[2] Charles Univ Prague, Fac Pharm, Dept Inorgan & Organ Chem, Hradec Kralove 50005, Czech Republic

[3] Univ Helsinki, Fac Pharm, Div Pharmaceut Biol & Drug Discovery, FIN-00014 Helsinki, Finland

[4] Univ Helsinki, Fac Pharm, Dev Technol Ctr, FIN-00014 Helsinki, Finland

[5] Abo Akad Univ, Fac Math & Nat Sci, Dept Biochem & Pharm, FIN-20521 Turku, Finland

来源：

FITOTERAPIA | 2006年 / 77卷 / 03期

关键词：

Leuzea carthamoides; photosensitizers; phototoxicity; polyacetylenes; polyynes;

D O I：

10.1016/j.fitote.2006.01.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The thiophene polyacetylene (E)-1-[5-(hept-5-en-1,3-diynyl)-2-thienyl]ethan-1,2-diol, isolated from the roots of Leuzea carthamoides, showed phototoxic activity in the assay systems of histidine photo-oxidation, Artemia and Tubifex assays. The effects were compared with the standard photosensitizer xanthotoxin. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：194 / 198

页数：5

共 33 条

[1]

Toxic effects and bioaccumulation of cadmium in the aquatic oligochaete Tubifex tubifex [J].

Bouché, ML ;

Habets, F ;

Biagianti-Risbourg, S ;

Vernet, G .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2000, 46 (03) :246-251

[2]

Chobot V., 2004, Central European Journal of Public Health, V12, pS31

[3]

Antifungal activity of a thiophene polyine from Leuzea carthamoides [J].

Chobot, V ;

Buchta, V ;

Jahodárová, H ;

Pour, M ;

Opletal, L ;

Jahodár, L ;

Harant, P .

FITOTERAPIA, 2003, 74 (03) :288-290

[4]

CONSTABEL CP, 1998, PLANTA MED, V55, P35

[5]

EPPLEY RM, 1974, J ASSOC OFF ANA CHEM, V57, P618

[6]

Multiple modes of insecticidal action of three classes of polyacetylene derivatives from Rudbeckia hirta [J].

Guillet, G ;

Philogene, BJR ;

OMeara, J ;

Durst, T ;

Arnason, JT .

PHYTOCHEMISTRY, 1997, 46 (03) :495-498

[7]

Hadacek F, 2000, PHYTOCHEM ANALYSIS, V11, P137, DOI 10.1002/(SICI)1099-1565(200005/06)11:3&lt

[8]

137::AID-PCA514&gt

[9]

3.0.CO

[10]

2-I

← 1 2 3 4 →