Sclerostin in Mineralized Matrices and van Buchem Disease

被引：155

作者：

van Bezooijen, R. L. ^{[1
]}

Bronckers, A. L. ^{[5
]}

Gortzak, R. A. ^{[2
]}

Hogendoorn, P. C. W. ^{[3
]}

van der Wee-Pals, L. ^{[1
]}

Balemans, W. ^{[7
,8
]}

Oostenbroek, H. J. ^{[4
]}

Van Hul, W. ^{[7
,8
]}

Hamersma, H. ^{[9
]}

Dikkers, F. G. ^{[6
]}

Hamdy, N. A. T. ^{[1
]}

Papapoulos, S. E. ^{[1
]}

Lowik, C. W. G. M. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, NL-2333 ZA Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Oral & Maxillofacial Surg, NL-2333 ZA Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Pathol, NL-2333 ZA Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Dept Orthopaed, NL-2333 ZA Leiden, Netherlands

[5] ACTA, Amsterdam, Netherlands

[6] Univ Groningen, Univ Med Ctr Groningen, NL-9700 AB Groningen, Netherlands

[7] Univ Antwerp, Antwerp, Belgium

[8] Univ Antwerp Hosp, Antwerp, Belgium

[9] Flora Clin, Roodepoort, South Africa

来源：

JOURNAL OF DENTAL RESEARCH | 2009年 / 88卷 / 06期

关键词：

sclerostin; osteocytes; cementocytes; chondrocytes; van Buchem disease; BONE-FORMATION; SOST GENE; BMP ANTAGONIST; DELETION; WNT; HYPEROSTOSIS; OSTEOCYTES; DENSITY; PRODUCT; PROTEIN;

D O I：

10.1177/0022034509338340

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Sclerostin is an inhibitor of bone formation expressed by osteocytes. We hypothesized that sclerostin is expressed by cells of the same origin and also embedded within mineralized matrices. In this study, we analyzed (a) sclerostin expression using immunohistochemistry, (b) whether the genomic defect in individuals with van Buchem disease (VBD) was associated with the absence of sclerostin expression, and (c) whether this was associated with hypercementosis. Sclerostin was expressed by cementocytes in mouse and human teeth and by mineralized hypertrophic chondrocytes in the human growth plate. In individuals with VBD, sclerostin expression was absent or strongly decreased in osteocytes and cementocytes. This was associated with increased bone formation, but no overt changes in cementum thickness. In conclusion, sclerostin is expressed by all 3 terminally differentiated cell types embedded within mineralized matrices: osteocytes, cementocytes, and hypertrophic chondrocytes.

引用

页码：569 / 574

页数：6

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