Stimulation of B lymphocytes, macrophages, and dendritic cells by protozoan DNA

被引：17

作者：

Brown, WC ^{[1
]}

Corral, RS

机构：

[1] Washington State Univ, Dept Vet Microbiol & Pathol, Program Vector Borne Dis, Pullman, WA 99164 USA

[2] Hosp Ninos Dr Ricardo Gutierrez, Virol Lab, RA-1425 Buenos Aires, DF, Argentina

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 09期

关键词：

protozoa; CpG DNA; innate immunity;

D O I：

10.1016/S1286-4579(02)01623-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review summarizes recent work from our laboratory demonstrating the activation of B lymphocytes, macrophages and dendritic cells by DNA from three different protozoan parasites of cattle and humans that is qualitatively similar to the now well-described effects of CpG-containing bacterial DNA. This novel mechanism of protozoan parasite recognition by the innate immune system could facilitate recovery from acute infection or contribute to infection-related pathology. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

收藏

页码：969 / 974

页数：6

相关论文

共 53 条

[1] IFN-γ in human Chagas' disease:: Protection or pathology? [J].

Bahia-Oliveira, LMG ;

Gomes, JAS ;

Rocha, MOC ;

Moreira, MCV ;

Lemos, EM ;

Luz, ZMP ;

Pereira, MES ;

Coffman, RL ;

Dias, JCP ;

Cancado, JR ;

Gazzinelli, G ;

Correa-Oliveira, R .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1998, 31 (01) :127-131

[2]

Ballas ZK, 1996, J IMMUNOL, V157, P1840

[3] Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition [J].

Bauer, S ;

Kirschning, CJ ;

Häcker, H ;

Redecke, V ;

Hausmann, S ;

Akira, S ;

Wagner, H ;

Lipford, GB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9237-9242

[4] Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease [J].

Brener, Z ;

Gazzinelli, RT .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1997, 114 (02) :103-110

[5] BOVINE T-CELL CLONES INFECTED WITH THEILERIA-PARVA PRODUCE A FACTOR WITH IL-2-LIKE ACTIVITY [J].

BROWN, WC ;

LOGAN, KS .

PARASITE IMMUNOLOGY, 1986, 8 (02) :189-192

[6] DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells [J].

Brown, WC ;

Estes, DM ;

Chantler, SE ;

Kegerreis, KA ;

Suarez, CE .

INFECTION AND IMMUNITY, 1998, 66 (11) :5423-5432

[7] Pathogenesis of malaria [J].

Clark, IA ;

Schofield, L .

PARASITOLOGY TODAY, 2000, 16 (10) :451-454

[8]

Estes DM, 1998, IMMUNOLOGY, V95, P604

[9] Danger signals: SOS to the immune system [J].

Gallucci, S ;

Matzinger, P .

CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (01) :114-119

[10]

Gao JJ, 1999, J IMMUNOL, V163, P4095

← 1 2 3 4 5 6 →