Caspases: killer proteases

被引：2084

作者：

Nicholson, DW ^{[1
]}

Thornberry, NA ^{[1
]}

机构：

[1] MERCK RES LABS,DEPT ENZYMOL,RAHWAY,NJ 07065

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(97)01085-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key and central role that these enzymes play in a biochemical cell-suicide pathway has been conserved throughout the evolution of multicellular eukaryotes.

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页码：299 / 306

页数：8

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