Synthesis and antibacterial activity evaluation of metronidazole-triazole conjugates

被引：71

作者：

Beena ^{[1
]}

Kumar, Nitin ^{[1
]}

Rohilla, Rajesh K. ^{[2
]}

Roy, N. ^{[2
]}

Rawat, Diwan S. ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

[2] Natl Inst Pharmaceut Educ & Res, Dept Biotechnol, Sas Nagar 160062, Punjab, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 05期

关键词：

Metronidazole; Triazole; Antbacterial activity; TRICHOMONAS-VAGINALIS; IN-VITRO; ENEDIYNES; BACTERIA; CANCER;

D O I：

10.1016/j.bmcl.2009.01.037

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Synthesis and antibacterial activity of metronidazole-triazole conjugates are reported. Total 21 hybrid compounds have been synthesized with different substitution pattern on the triazole ring in order to study their influence on the antibacterial activity. These compounds demonstrated potent to weak antibacterial activity against Gram-positive, and Gram-negative bacteria. Six compounds have shown equal or better antibacterial activity against Gram-negative strains than the reference compound. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1396 / 1398

页数：3

共 28 条

[1]

Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes [J].