Mechanisms controlling pathogenesis and survival of leukemic stem cells

被引：108

作者：

Jordan, CT ^{[1
]}

Guzman, ML ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USA

来源：

ONCOGENE | 2004年 / 23卷 / 43期

关键词：

leukemia; stem cell; myeloid; leukemogenesis; NF-kappa B; LSC;

D O I：

10.1038/sj.onc.1207935

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stem cells are an integral component of normal mammalian physiology and have been intensively studied in many systems. Intriguingly, substantial evidence indicates that stem cells also play an important role in the initiation and pathogenesis of at least some cancers. In particular, myeloid leukemias have been extensively characterized with regard to stem and progenitor cell involvement. Thus, as a focal point for both scientific and therapeutic endeavors, leukemic stem cells (LSC) represent a critical area of investigation. LSC appear to retain many characteristics of normal hematopoietic stem cells (HSC) as evidenced by a hierarchical developmental pattern, a mostly quiescent cell cycle pro. le, and an immunophenotype very similar to HSC. Consequently, de. ning unique properties of LSC remains a high priority in order to elucidate the molecular mechanisms driving stem cell transformation, and for developing therapeutic strategies that specifically target the LSC population. In this review, we discuss emerging concepts in the field and describe how various molecular and cellular characteristics of leukemia cells might be exploited as a means to preferentially ablate malignant stem cells.

引用

页码：7178 / 7187

页数：10

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