Aminoglycoside - RNA interactions

被引：179

作者：

Walter, F ^{[1
]}

Vicens, Q ^{[1
]}

Westhof, E ^{[1
]}

机构：

[1] CNRS, Inst Biol Mol & Cellulaire, UPR 9002, F-67084 Strasbourg, France

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 06期

关键词：

D O I：

10.1016/S1367-5931(99)00028-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structural and physico-chemical parameters promoting the binding of aminoglycosides to RNAs are becoming clear. The strength of the interaction is dominated by electrostatics, with the positively charged aminoglycosides displacing metal ions. Although aminoglycosides inhibit most known ribozymes, aminoglycosides or polyamines are able to catalyze specific RNA cleavage in the absence of metal ions.

引用

页码：694 / 704

页数：11

共 93 条

[1] Probing the specificity of aminoglycoside ribosomal RNA interactions with designed synthetic analogs [J].

Alper, PB ;

Hendrix, M ;

Sears, P ;

Wong, CH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (09) :1965-1978

[2] The structure, function and application of the hammerhead ribozyme [J].

Birikh, KR ;

Heaton, PA ;

Eckstein, F .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 245 (01) :1-16

[3] RRNA chemical groups required for aminoglycoside binding [J].

Blanchard, SC ;

Fourmy, D ;

Eason, RG ;

Puglisi, JD .

BIOCHEMISTRY, 1998, 37 (21) :7716-7724

[4] ARGININE-MEDIATED RNA RECOGNITION - THE ARGININE FORK [J].

CALNAN, BJ ;

TIDOR, B ;

BIANCALANA, S ;

HUDSON, D ;

FRANKEL, AD .

SCIENCE, 1991, 252 (5009) :1167-1171

[5]

CALNAN BJ, 1992, SCIENCE, V255, P665

[6]

CECH TR, 1993, RNA WORLD, P239

[7] Inhibition of hepatitis delta virus genomic ribozyme self-cleavage by aminoglycosides [J].

Chia, JS ;

Wu, HL ;

Wang, HW ;

Chen, DS ;

Chen, PJ .

JOURNAL OF BIOMEDICAL SCIENCE, 1997, 4 (05) :208-216

[8] A structural basis for RNA-ligand interactions [J].

Chow, CS ;

Bogdan, FM .

CHEMICAL REVIEWS, 1997, 97 (05) :1489-1513

[9] NEOMYCIN INHIBITION OF THE HAMMERHEAD RIBOZYME INVOLVES IONIC INTERACTIONS [J].

CLOUETDORVAL, B ;

STAGE, TK ;

UHLENBECK, OC .

BIOCHEMISTRY, 1995, 34 (35) :11186-11190

[10] Crystal structure of a conserved ribosomal protein-RNA complex [J].

Conn, GL ;

Draper, DE ;

Lattman, EE ;

Gittis, AG .

SCIENCE, 1999, 284 (5417) :1171-1174

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