Structural commonalities among integral membrane enzymes

被引：42

作者：

Bracey, MH

Cravatt, BF

Stevens, RC

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

FEBS LETTERS | 2004年 / 567卷 / 2-3期

关键词：

membrane proteins; protein structure;

D O I：

10.1016/j.febslet.2004.04.084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The X-ray crystal structures of five distinct enzymes (prostaglandin H-2 synthase, squalene cyclase, fatty acid amide hydrolase, microsomal cytochrome P450, and estrone sulfatase) challenge contemporary descriptions of integral membrane proteins. This structurally divergent group represents an important component of the integral membrane proteome that lies at the bilayer's aqueous interface. We summarize here what is collectively understood about the membrane insertion of these proteins, what roles they may play in lipid biology, and their relationship to soluble structural homologs. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

收藏

页码：159 / 165

页数：7

相关论文

共 61 条

[1] CHARACTERIZATION AND PARTIAL-PURIFICATION OF SQUALENE-2,3-OXIDE CYCLASE FROM SACCHAROMYCES-CEREVISIAE [J].

BALLIANO, G ;

VIOLA, F ;

CERUTI, M ;

CATTEL, L .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 293 (01) :122-129

[2]

Becker OM, 2003, CURR OPIN DRUG DISC, V6, P353

[3] Structure-function relationships in flavoenzyme-dependent amine oxidations. A comparison of polyamine oxidase and monoamine oxidase. [J].

Binda, C ;

Mattevi, A ;

Edmondson, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :23973-23976

[4] A 30 Å long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase [J].

Binda, C ;

Coda, A ;

Angelini, R ;

Federico, R ;

Ascenzi, P ;

Mattevi, A .

STRUCTURE, 1999, 7 (03) :265-276

[5] Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders [J].

Binda, C ;

Newton-Vinson, P ;

Hubálek, F ;

Edmondson, DE ;

Mattevi, A .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (01) :22-26

[6] INTRACELLULAR PROTEIN TOPOGENESIS [J].

BLOBEL, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (03) :1496-1500

[7] The plant S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase is located in both envelope and thylakoid chloroplast membranes [J].

Block, MA ;

Tewari, AK ;

Albrieux, C ;

Maréchal, E ;

Joyard, J .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (01) :240-248

[8] Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling [J].

Bracey, MH ;

Hanson, MA ;

Masuda, KR ;

Stevens, RC ;

Cravatt, BF .

SCIENCE, 2002, 298 (5599) :1793-1796

[9] COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression [J].

Chandrasekharan, NV ;

Dai, H ;

Roos, KLT ;

Evanson, NK ;

Tomsik, J ;

Elton, TS ;

Simmons, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13926-13931

[10] FOLDING PATTERN DIVERSITY OF INTEGRAL MEMBRANE-PROTEINS [J].

COWAN, SW ;

ROSENBUSCH, JP .

SCIENCE, 1994, 264 (5161) :914-916

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